Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington’s disease

Researchers from the Subcellular Architecture group of the CINN and the Health Research Institute of the Principality of Asturias (ISPA) identify, through three-dimensional electron microscopy and molecular techniques, alterations in neuronal polysomal architecture in animal models of Huntington’s disease.

These findings indicate that changes in the architecture of the protein synthesis machinery may underlie translational alterations associated with Huntington’s disease, opening new avenues for understanding the progression of the disease.

This work has been performed in collaboration with researchers from National Centre for Biotechnology (CNB-CSIC), the MRC Laboratory of Molecular Biology of the Cambridge Biomedical Campus, the “Severo Ochoa” Molecular Biology Centre (CSIC-UAM) and the Departament of Molecular Biology of the Autonomous University of Madrid (UAM), has been recentñy published in “Neurobiology of Disease“.